Description

6-Chloro-2-Trifluoromethoxy-Pyridin-3-Ylamine is a high-purity, multi-functional pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique combination of halogen and trifluoromethoxy substituents, which are essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science Research: Employed as a precursor for creating specialized ligands, functionalized polymers, and liquid crystal materials.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and enzyme inhibitors in biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific halogenated pyridine core.

Basic Information

Product Name	6-Chloro-2-Trifluoromethoxy-Pyridin-3-Ylamine
CAS No.	1221171-93-2
Molecular Formula	C7H4ClF3N2O
Molecular Weight	224.57 g/mol
Synonyms	3-Amino-6-chloro-2-(trifluoromethoxy)pyridine; 6-Chloro-2-(trifluoromethoxy)pyridin-3-amine; 2-Trifluoromethoxy-6-chloropyridin-3-amine; 6-Chloro-2-trifluoromethoxy-3-aminopyridine; 3-Pyridinamine, 6-chloro-2-(trifluoromethoxy)-; 6-Chloro-2-(trifluoromethoxy)-3-pyridinamine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Trifluoromethoxy-Pyridin-3-Ylamine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP-aligned synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.