Description

6-Chloro-2-(trifluoromethoxy)nicotinic acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated pyridinecarboxylic acid structure. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D and fine chemical synthesis companies need it to develop next-generation therapeutics with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in developing new-generation herbicides and pesticides with improved activity profiles.
• Material Science: Serves as a monomer or functional additive for creating specialty polymers with unique fluorinated properties.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalytic and metal-organic framework (MOF) applications.
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	6-Chloro-2-(trifluoromethoxy)nicotinic Acid
CAS No.	1221171-91-0
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	2-(Trifluoromethoxy)-6-chloronicotinic acid; 6-Chloro-2-(trifluoromethoxy)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-chloro-2-(trifluoromethoxy)-; 6-Chloro-2-trifluoromethoxynicotinic acid; 1221171-91-0; Nicotinic acid, 6-chloro-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-(trifluoromethoxy)nicotinic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.