Description

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic and pharmaceutical scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where the picolinonitrile core and boronic ester handle allow for modular construction.
• Chemical Biology: Serves as a versatile probe or linker in bioconjugation and the development of chemical tools for biological target identification.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds with high efficiency and functional group tolerance.
• Library Synthesis: A valuable reagent for medicinal chemistry teams engaged in high-throughput screening and combinatorial library generation to explore new chemical space.

Basic Information

Product Name	3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
CAS No.	1220219-63-5
Molecular Formula	C₁₂H₁₄BClN₂O₂
Molecular Weight	264.51 g/mol
Synonyms	3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; 3-Chloro-5-(pinacolatoboryl)picolinonitrile; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chloropicolinonitrile; Pinacol 3-chloro-5-cyanopyridine-2-boronate; 1220219-63-5; 3-Chloro-5-(pinacolboronato)picolinonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.