Description

2-{4-[3-Amino-4-(Ethylsulfonyl)Phenyl]-1-Piperazinyl}-1-Ethanol is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperazine and ethanolamine-substituted aromatic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and receptor-targeted therapies.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic molecules and studying structure-activity relationships (SAR).
• API Development: Serves as a precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Bioconjugation Chemistry: The amino and hydroxyl functional groups make it suitable for linker chemistry in the development of antibody-drug conjugates (ADCs) or prodrugs.

Basic Information

Product Name	2-{4-[3-Amino-4-(Ethylsulfonyl)Phenyl]-1-Piperazinyl}-1-Ethanol
CAS No.	1220039-23-5
Molecular Formula	C14H23N3O3S
Molecular Weight	313.42 g/mol
Synonyms	2-[4-[3-Amino-4-(ethylsulfonyl)phenyl]piperazin-1-yl]ethanol; 1-[3-Amino-4-(ethylsulfonyl)phenyl]-4-(2-hydroxyethyl)piperazine; 2-(4-(3-Amino-4-(ethylsulfonyl)phenyl)piperazin-1-yl)ethan-1-ol; 1220039-23-5; Amino Ethylsulfonyl Phenyl Piperazine Ethanol; AE-PPE Intermediate
EINECS	Contact for details

Quality Control

Our 2-{4-[3-Amino-4-(Ethylsulfonyl)Phenyl]-1-Piperazinyl}-1-Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.