Description

2-(3-Piperidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct trifluoromethylpyridine core. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within the central nervous system (CNS) and oncology domains.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique piperidinyloxy and trifluoromethyl motifs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of potential APIs for preclinical and clinical trials.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Product Name	2-(3-Piperidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride
CAS No.	1220037-04-6
Molecular Formula	C11H14F3N2O·HCl
Molecular Weight	280.70 g/mol
Synonyms	5-(Trifluoromethyl)-2-(3-piperidinyloxy)pyridine hydrochloride; 2-(Piperidin-3-yloxy)-5-(trifluoromethyl)pyridine HCl; 2-(3-Piperidyloxy)-5-trifluoromethylpyridine hydrochloride; 1220037-04-6; 5-(Trifluoromethyl)-2-(piperidin-3-yloxy)pyridine monohydrochloride
EINECS	Contact for details

Quality Control

Our 2-(3-Piperidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.