Description

2-(3-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its complex molecular architecture, which incorporates a trifluoromethylpyridine moiety linked to a piperidine ring, making it a versatile intermediate for creating novel bioactive molecules. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Ligand and Probe Synthesis: Employed in the creation of specialized chemical probes for biological target identification and validation.
• Agrochemical Research: Potential intermediate in the development of advanced crop protection agents, leveraging the physicochemical properties of the trifluoromethyl group.

Basic Information

Product Name	2-(3-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride
CAS No.	1220028-64-7
Molecular Formula	C12H15F3N2O·HCl
Molecular Weight	295.72 g/mol
Synonyms	5-(Trifluoromethyl)-2-[(3-piperidinyl)methoxy]pyridine hydrochloride; 2-[(Piperidin-3-yl)methoxy]-5-(trifluoromethyl)pyridine hydrochloride; 2-(3-Piperidylmethoxy)-5-trifluoromethylpyridine HCl; (R/S)-2-((Piperidin-3-yl)methoxy)-5-(trifluoromethyl)pyridine hydrochloride; 2-(Piperidin-3-ylmethoxy)-5-(trifluoromethyl)pyridine hydrochloride; 5-Trifluoromethyl-2-(3-piperidylmethoxy)pyridine hydrochloride; 2-(3-Piperidinylmethoxy)-5-(trifluoromethyl)pyridine HCl salt
EINECS	Contact for details

Quality Control

Our 2-(3-Piperidinylmethoxy)-5-(Trifluoromethyl)-Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if opened, and desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.