Description

1-Pyrrolidinyl(4,5,6,7-Tetrahydro-1H-Pyrazolo-[4,3-C]Pyridin-3-Yl)Methanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1219976-21-2. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a critical building block in the multi-step production of complex active pharmaceutical ingredients (APIs).
• CNS Drug Development: Particularly relevant for research into compounds interacting with specific neurotransmitter systems.
• Oncology Research: Employed in the development of kinase inhibitors and other targeted cancer therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	1-Pyrrolidinyl(4,5,6,7-Tetrahydro-1H-Pyrazolo-[4,3-C]Pyridin-3-Yl)Methanone Hydrochloride
CAS No.	1219976-21-2
Molecular Formula	C11H16N4O · HCl
Molecular Weight	248.73 g/mol (Free base)
Synonyms	1-(4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-pyrrolidin-1-ylethanone hydrochloride; 3-(1-Pyrrolidinylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride; 1-Pyrrolidinyl(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)methanone HCl; Pyrazolopyridine Derivative; Tetrahydro-pyrazolopyridine carboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinyl(4,5,6,7-Tetrahydro-1H-Pyrazolo-[4,3-C]Pyridin-3-Yl)Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.