Description

3-(2-Bromo-Acetyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a reactive bromoacetyl group on a protected piperidine scaffold. This compound is critical for medicinal chemists as it enables efficient and selective functionalization, serving as a key building block in the synthesis of complex bioactive molecules. It is primarily utilized in research and development for creating novel drug candidates targeting the central nervous system (CNS), oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the bromoacetyl moiety for further derivatization.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors targeting specific enzymes, such as proteases and kinases.
• Peptidomimetic Synthesis: Employed to construct non-peptide scaffolds that mimic the structure and function of peptides for enhanced drug-like properties.
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3-(2-Bromo-Acetyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1219813-78-1
Molecular Formula	C12H20BrNO3
Molecular Weight	306.20 g/mol
Synonyms	1-Boc-3-(2-bromoacetyl)piperidine; tert-Butyl 3-(2-bromoacetyl)piperidine-1-carboxylate; 3-(Bromoacetyl)-1-(tert-butoxycarbonyl)piperidine; 1-(tert-Butoxycarbonyl)-3-(2-bromoacetyl)piperidine; 3-(2-Bromoacetyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-(bromoacetyl)piperidine; 3-(Bromoacetyl)-N-Boc-piperidine
EINECS	Contact for details

Quality Control

Our 3-(2-Bromo-Acetyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results. We support development and commercial projects with material suitable for research use and can supply grades compliant with cGMP guidelines for advanced clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.