Description

6-Phenyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key chiral building block, enabling the construction of sophisticated molecular architectures with precise stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and commercial synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Serves as a key building block for constructing complex, nitrogen-containing heterocycles found in active pharmaceutical ingredients.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its piperidine core structure.
• Asymmetric Catalysis: Employed as a precursor or ligand in asymmetric synthesis to induce chirality in target molecules.
• Chemical Biology: Utilized as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	6-Phenyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1219175-87-7
Molecular Formula	C18H25NO4
Molecular Weight	319.40 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-6-phenylpiperidine-2-carboxylic acid; 6-Phenyl-2-piperidinecarboxylic acid 1-(1,1-dimethylethyl) ester; 1-Boc-6-phenylpipecolic acid; tert-Butyl 6-phenyl-2-piperidinecarboxylate-1-carboxylate; 6-Phenyl-1,2-piperidinedicarboxylic acid 1-tert-butyl ester; (2S,6R)-1-tert-Butyl 2-methyl 6-phenylpiperidine-1,2-dicarboxylate (stereoisomer); 6-Phenyl-DL-pipecolic acid N-Boc derivative
EINECS	Contact for details

Quality Control

Our 6-Phenyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical and chiral purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.