Description

4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl CAS NO 1219153-60-2 is a high-purity, protected piperazine carboxylic acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, nitrogen-containing scaffold with orthogonal protecting groups, enabling precise molecular construction. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex active pharmaceutical ingredients (APIs), peptidomimetics, and novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetics Research: Used to construct constrained peptide analogs and modify peptide backbones to enhance stability and bioavailability.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in multi-step synthetic routes for client-specific targets.
• Academic & Discovery Chemistry: Utilized in medicinal chemistry programs for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl
CAS No.	1219153-60-2
Molecular Formula	C15H21N2O4 • HCl
Molecular Weight	328.80 g/mol (Free base: 293.34 g/mol)
Synonyms	Methyl 1-[(benzyloxy)carbonyl]-4-piperazinecarboxylate hydrochloride; 1-CBZ-4-PIPERAZINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE; Methyl 1-(benzyloxycarbonyl)piperazine-4-carboxylate hydrochloride; 1-N-CBZ-Piperazine-4-carboxylic acid methyl ester HCl; 1-Carbobenzyloxy-piperazine-4-carboxylic acid methyl ester hydrochloride; 1-[(Benzyloxy)carbonyl]piperazine-4-carboxylic acid methyl ester hydrochloride; Z-Pip-OMe•HCl
EINECS	Contact for details

Quality Control

Our 4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.