Description

1-[2-Nitro-4-(Trifluoromethyl)Phenyl]Piperidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine carboxylic acid core substituted with a nitro and trifluoromethyl phenyl group. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperidine scaffold and electron-withdrawing substituents.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, leveraging the stability imparted by the trifluoromethyl group.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical products.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	1-[2-Nitro-4-(Trifluoromethyl)Phenyl]Piperidine-2-Carboxylic Acid
CAS No.	1219146-99-2
Molecular Formula	C13H13F3N2O4
Molecular Weight	318.25 g/mol
Synonyms	2-Piperidinecarboxylic acid, 1-[2-nitro-4-(trifluoromethyl)phenyl]-; 1-(2-Nitro-4-trifluoromethylphenyl)piperidine-2-carboxylic acid; 1-[2-Nitro-4-(trifluoromethyl)phenyl]-2-piperidinecarboxylic acid; 1-(2-Nitro-4-(trifluoromethyl)phenyl)piperidine-2-carboxylic acid; 1219146-99-2; 2-Piperidinecarboxylic acid, 1-[2-nitro-4-(trifluoromethyl)phenyl]-, (2S)-; (S)-1-(2-Nitro-4-(trifluoromethyl)phenyl)piperidine-2-carboxylic acid (if chiral)
EINECS	Contact for details

Quality Control

Our 1-[2-Nitro-4-(Trifluoromethyl)Phenyl]Piperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.