Description

(R)-1-Cbz-3-(Aminomethyl)Piperidine is a high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality—a protected amine and a chiral center—which enables the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds. Its defined stereochemistry ensures consistent results in asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used as a versatile chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereochemical complexity.
• Peptidomimetics & Drug Discovery: Incorporated into peptide backbones to create stable, drug-like molecules with improved pharmacokinetic properties.
• Agrochemical Research: Serves as a building block for synthesizing novel chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	(R)-1-Cbz-3-(Aminomethyl)Piperidine
CAS No.	1217977-11-1
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-3-(aminomethyl)piperidine; (R)-3-(Aminomethyl)-1-Cbz-piperidine; (R)-N-Carbobenzoxy-3-(aminomethyl)piperidine; (R)-1-Cbz-3-piperidinemethanamine; (3R)-1-[(Phenylmethoxy)carbonyl]-3-piperidinemethanamine; (R)-1-(Benzyloxycarbonyl)-3-(aminomethyl)piperidine; (R)-1-Cbz-3-(aminomethyl)piperidine; Benzyl (3R)-3-(aminomethyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-1-Cbz-3-(Aminomethyl)Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support development from research to commercial scale with material produced under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.