Description

(R)-1-Cbz-3-Isopropyl-Piperazine is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly for creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Peptidomimetics Development: Incorporated into the design of peptide-like molecules to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for the custom production of complex, high-value specialty chemicals.

Basic Information

Product Name	(R)-1-Cbz-3-Isopropyl-Piperazine
CAS No.	1217975-31-9
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(R)-1-(Benzyloxycarbonyl)-3-(propan-2-yl)piperazine; (R)-1-Carbobenzoxy-3-isopropylpiperazine; (R)-N-Cbz-3-Isopropylpiperazine; (R)-3-Isopropyl-1-(phenylmethoxy)carbonylpiperazine; (R)-1-[(Benzyloxy)carbonyl]-3-(1-methylethyl)piperazine; (R)-1-Cbz-3-(i-Pr)-Piperazine; (R)-CBZ-3-ISO-PROPYL-PIPERAZINE
EINECS	Contact for details

Quality Control

Our (R)-1-Cbz-3-Isopropyl-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. While not intended as an API, production follows principles aligned with ICH guidelines for impurities in drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.