Description

(R)-Benzyl 3-Methylpiperazine-1-Carboxylate Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its primary value lies in providing a stereochemically defined scaffold for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. This compound is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing who require reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting neurological disorders.
• API Development: Used in the research and process development of novel Active Pharmaceutical Ingredients (APIs), especially in oncology and psychopharmacology.
• Asymmetric Synthesis: Employed as a building block to introduce the (R)-3-methylpiperazine moiety in asymmetric catalytic and stoichiometric reactions.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and lead optimization programs within pharmaceutical discovery.
• Fine Chemical Production: Serves as a precursor for the manufacture of more complex, high-value specialty chemicals and advanced intermediates.
• Contract Manufacturing (CMO): Supplied to Contract Manufacturing Organizations for the production of clinical trial materials and commercial APIs under GMP guidelines.

Basic Information

Product Name	(R)-Benzyl 3-Methylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1217831-52-1
Molecular Formula	C14H21ClN2O2
Molecular Weight	284.78 g/mol
Synonyms	(R)-Benzyl 3-methylpiperazine-1-carboxylate HCl; (R)-1-Benzyloxycarbonyl-3-methylpiperazine hydrochloride; (R)-Cbz-3-methylpiperazine hydrochloride; (R)-1-N-Cbz-3-methylpiperazine hydrochloride; (3R)-1-[(Benzyloxy)carbonyl]-3-methylpiperazine hydrochloride; (R)-3-Methyl-1-(phenylmethoxy)carbonylpiperazine hydrochloride; (R)-1-(Benzyloxycarbonyl)-3-methylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Benzyl 3-Methylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates, supporting our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.