Description

(R) 1-Boc-2-(Methylcarbamoyl)Piperazine-Hcl is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly for chiral drugs targeting the central nervous system and other therapeutic areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing complex molecular architectures where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially for neurological and psychiatric disorders.
• Peptidomimetics & PROTACs Development: Serves as a constrained scaffold or linker component in the design of peptide mimics and proteolysis-targeting chimeras.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chirality into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for custom synthesis projects requiring high stereochemical purity.
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(R) 1-Boc-2-(Methylcarbamoyl)Piperazine-Hcl
CAS No.	1217826-94-2
Molecular Formula	C12H23ClN4O3
Molecular Weight	306.79 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-(methylcarbamoyl)piperazine hydrochloride; (R)-1-Boc-2-(N-Methylaminocarbonyl)piperazine HCl; (R)-N-Boc-N'-(methylaminocarbonyl)piperazine hydrochloride; (R)-tert-Butyl 2-(methylcarbamoyl)piperazine-1-carboxylate hydrochloride; (R)-1-Boc-2-(Methylaminocarbonyl)piperazine HCl; (R)-1-Boc-2-(N-Methylcarbamoyl)piperazine hydrochloride; (R)-Piperazine-1-carboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our (R) 1-Boc-2-(Methylcarbamoyl)Piperazine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Production adheres to cGMP guidelines where applicable, supporting its use in pharmaceutical development. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. We support our clients' regulatory submissions with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.