Description

(R) 1-Boc-2-(Dimethylcarbamoyl)Piperazine-Hcl is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs) and complex molecules. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Synthesis: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• API Process Development: Employed in route scouting and scale-up studies for the commercial manufacturing of complex active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(R) 1-Boc-2-(Dimethylcarbamoyl)Piperazine-Hcl
CAS No.	1217825-46-1
Molecular Formula	C12H24ClN3O3
Molecular Weight	293.79 g/mol
Synonyms	(R)-1-Boc-2-(N,N-Dimethylcarbamoyl)piperazine hydrochloride; tert-Butyl (R)-2-(dimethylcarbamoyl)piperazine-1-carboxylate hydrochloride; (R)-1-(tert-Butoxycarbonyl)-2-(dimethylaminocarbonyl)piperazine hydrochloride; (R)-N-Boc-2-(dimethylcarbamoyl)piperazine HCl; (R)-1-Boc-2-piperazinecarboxamide, N,N-dimethyl-, hydrochloride; (R)-2-(Dimethylcarbamoyl)-1-Boc-piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R) 1-Boc-2-(Dimethylcarbamoyl)Piperazine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.