Description

(R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine is a high-purity, chiral piperazine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex drug molecules. Its value lies in providing a protected, stereochemically defined scaffold that enables the efficient construction of pharmacologically active compounds, particularly in small molecule drug discovery and development. This compound is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for creating targeted therapies.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology, antiviral, and central nervous system (CNS) drug candidates.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptidomimetics and constrained peptides due to its piperazine core and hydroxymethyl functionality.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed in the development of molecular probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.
• Protecting Group Strategy: The Boc and Cbz protecting groups allow for selective deprotection, facilitating complex multi-step synthetic routes.

Basic Information

Product Name	(R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine
CAS No.	1217813-68-7
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)-(2R)-2-(hydroxymethyl)piperazine; (R)-1-Cbz-4-Boc-2-hydroxymethylpiperazine; (R)-1-Benzyloxycarbonyl-4-tert-butoxycarbonyl-2-hydroxymethylpiperazine; (R)-N-Cbz-N'-Boc-2-hydroxymethylpiperazine; (2R)-2-(Hydroxymethyl)-1-[(phenylmethoxy)carbonyl]-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine; (R)-4-(tert-Butoxycarbonyl)-1-(benzyloxycarbonyl)-2-(hydroxymethyl)piperazine; (R)-1-Boc-4-Cbz-2-Hydroxymethylpiperazine (common numbering variation); Boc-Cbz-(R)-2-Hydroxymethylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-4-Boc-1-Cbz-2-Hydroxymethylpiperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.