Description

(S)-3-Methoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected, stereochemically defined piperazine scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is particularly vital for research and development chemists and process scale-up teams in the pharmaceutical industry, where it is used to synthesize active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, antiviral agents, and other therapeutic compounds requiring a specific (S)-configured piperazine moiety.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptidomimetics and constrained peptides, where the tert-butyloxycarbonyl (Boc) and methyl ester groups offer orthogonal protection strategies.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the construction of molecular probes and tool compounds for studying biological targets and pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	(S)-3-Methoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1217810-25-7
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	(S)-1-Boc-3-(methoxycarbonylmethyl)piperazine; (S)-1-(tert-Butoxycarbonyl)-3-(carboxymethyl)piperazine Methyl Ester; (S)-3-(Methoxycarbonylmethyl)-1-Boc-piperazine; (S)-tert-Butyl 3-(methoxycarbonylmethyl)piperazine-1-carboxylate; (S)-1-Boc-3-(methoxycarbonylmethyl)piperazine; (S)-N-Boc-3-(methoxycarbonylmethyl)piperazine; (S)-3-(Methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of (S)-3-Methoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. Comprehensive analytical testing, including chiral purity verification, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.