Description

R-3-n-Boc-Aminomethyl Piperidine-Hcl is a high-purity, protected piperidine derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for introducing a functionalized piperidine scaffold with a Boc-protected aminomethyl group, enabling precise molecular construction. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), particularly in the synthesis of complex molecules targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Peptide Mimetics & Conjugation: Used to incorporate a rigid, nitrogen-containing heterocycle into peptide backbones to enhance stability and bioavailability.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Building Block for Chemical Libraries: Employed in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening.
• Agrochemical Research: Utilized in the synthesis of advanced crop protection agents and herbicides requiring specific stereochemistry.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	R-3-n-Boc-Aminomethyl Piperidine-Hcl
CAS No.	1217778-64-7
Molecular Formula	C12H24N2O2 • HCl
Molecular Weight	264.79 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonylamino)methyl)piperidine hydrochloride; (R)-1-Boc-3-(aminomethyl)piperidine hydrochloride; (R)-N-Boc-3-piperidinemethanamine hydrochloride; (R)-3-(Boc-aminomethyl)piperidine HCl; (R)-tert-Butyl 3-(aminomethyl)piperidine-1-carboxylate hydrochloride; (3R)-3-[(tert-Butoxycarbonylamino)methyl]piperidine hydrochloride; (R)-1-N-Boc-3-aminomethylpiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our R-3-n-Boc-Aminomethyl Piperidine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.