Description

(R)-Benzyl 3-Benzylpiperazine-1-Carboxylate Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold essential for developing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas like central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• API Process Development: Used in route scouting and optimization for the commercial-scale production of complex active pharmaceutical ingredients.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries of compounds for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the (R)-configured piperazine moiety.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	(R)-Benzyl 3-Benzylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1217753-37-1
Molecular Formula	C20H24N2O2·HCl
Molecular Weight	360.88 g/mol
Synonyms	(R)-Benzyl 3-Benzylpiperazine-1-carboxylate HCl; (R)-1-Benzyloxycarbonyl-3-benzylpiperazine hydrochloride; (R)-CBZ-3-Benzylpiperazine hydrochloride; (R)-N-Carbobenzoxy-3-benzylpiperazine HCl; (R)-1-(Benzyloxycarbonyl)-3-benzylpiperazine hydrochloride; (R)-3-Benzyl-1-[(phenylmethoxy)carbonyl]piperazine hydrochloride; (R)-1-N-CBZ-3-Benzylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Benzyl 3-Benzylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.