Description

(S)-1-n-Cbz-2-Methyl-Piperazine -Hcl is a high-purity chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold essential for constructing complex molecules with high biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• API Synthesis: Used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) where the (S)-configured 2-methyl-piperazine moiety is required for target binding and efficacy.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Peptidomimetic Chemistry: Incorporated into the backbone of peptidomimetics to modulate pharmacokinetic properties and receptor selectivity.
• Chemical Biology & Proteomics: Utilized as a functionalized handle for creating chemical probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	(S)-1-n-Cbz-2-Methyl-Piperazine -Hcl
CAS No.	1217720-49-4
Molecular Formula	C14H21N3O2 • HCl
Molecular Weight	299.80 g/mol (as free base: 263.34 g/mol)
Synonyms	(S)-1-(Benzyloxycarbonyl)-2-methylpiperazine hydrochloride; (S)-1-Cbz-2-methylpiperazine hydrochloride; (S)-N-Carbobenzoxy-2-methylpiperazine hydrochloride; (S)-2-Methyl-1-(phenylmethoxy)carbonylpiperazine hydrochloride; (S)-1-[(Benzyloxy)carbonyl]-2-methylpiperazine hydrochloride; (2S)-1-[(Benzyloxy)carbonyl]-2-methylpiperazine hydrochloride; (S)-1-CBZ-2-Methylpiperazine HCl; (S)-2-Methyl-1-Cbz-piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-n-Cbz-2-Methyl-Piperazine -Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.