Description

(R)-4-n-Cbz-2-Ethylpiperazine-Hcl is a chiral piperazine derivative, a high-value building block in advanced pharmaceutical synthesis. Its primary value lies in its role as a key intermediate for constructing complex, biologically active molecules, particularly in the development of new therapeutic agents. This compound is essential for research and production in the pharmaceutical and biotechnology sectors, where precise stereochemistry is critical for drug efficacy and safety.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and development of peptide mimics for drug discovery programs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for novel drug targets.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(R)-4-n-Cbz-2-Ethylpiperazine-Hcl
CAS No.	1217699-53-0
Molecular Formula	C14H21N3O2 • HCl
Molecular Weight	299.80 g/mol
Synonyms	(R)-1-(Benzyloxycarbonyl)-4-ethylpiperazine hydrochloride; (R)-4-(Benzyloxycarbonyl)-2-ethylpiperazine hydrochloride; (R)-N-Cbz-2-Ethylpiperazine hydrochloride; (R)-2-Ethyl-4-(phenylmethoxycarbonyl)piperazine hydrochloride; (R)-1-Carbobenzoxy-4-ethylpiperazine HCl; (R)-4-(Cbz)-2-Ethylpiperazine HCl; (R)-4-(N-Carbobenzoxy)-2-ethylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-4-n-Cbz-2-Ethylpiperazine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.