Description

(R)-4-Benzyl 1-tert-Butyl 2-Methylpiperazine-1,4-Dicarboxylate is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly for chiral drugs requiring precise stereochemistry. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this material to synthesize complex molecules with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or auxiliaries used in stereoselective chemical transformations.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic scaffolds for medicinal chemistry programs.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom production of complex, high-value specialty chemicals for clients.
• Academic & Industrial R&D: Utilized in research laboratories for method development and exploring new synthetic routes to complex heterocycles.

Basic Information

Product Name	(R)-4-Benzyl 1-tert-Butyl 2-Methylpiperazine-1,4-Dicarboxylate
CAS No.	1217684-73-5
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	1-tert-Butyl 4-benzyl (2R)-2-methylpiperazine-1,4-dicarboxylate; (R)-1-Boc-4-Cbz-2-methylpiperazine; (R)-N-Boc-N'-Cbz-2-methylpiperazine; (R)-2-Methyl-1,4-bis(oxycarbonyl)piperazine, 1-tert-butyl 4-benzyl ester; (2R)-1-(tert-Butoxycarbonyl)-4-[(benzyloxy)carbonyl]-2-methylpiperazine; (R)-1,4-Bis(tert-butoxycarbonyl/benzyloxycarbonyl)-2-methylpiperazine; (R)-Boc-Cbz-2-methylpiperazine; (R)-2-Methylpiperazine-1,4-dicarboxylic acid 1-tert-butyl 4-benzyl ester
EINECS	Contact for details

Quality Control

Our (R)-4-Benzyl 1-tert-Butyl 2-Methylpiperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications for identity, purity, and impurities are provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.