Description

(R)-6-Hydroxymethyl-1-(4-Hydroxy-Phenyl)-Piperazin-2-One is a high-purity chiral piperazinone derivative, a critical advanced pharmaceutical intermediate (API intermediate) valued for its role in the synthesis of complex, biologically active molecules. Its significance lies in providing a stereochemically defined scaffold essential for developing new therapeutic agents, particularly in the central nervous system (CNS) and oncology research sectors. This compound is primarily needed by pharmaceutical R&D laboratories, custom synthesis houses, and manufacturers of active pharmaceutical ingredients (APIs) who require reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production route of complex APIs that require the specific (R)-enantiomer configuration for optimal biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in chiral pool synthesis and the development of stereoselective manufacturing processes.
• Contract Manufacturing & Development (CMO/CDMO): Supplied to organizations specializing in the custom synthesis of complex organic molecules for clinical trial materials.
• Reference Standard: Can be utilized as an analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	(R)-6-Hydroxymethyl-1-(4-Hydroxy-Phenyl)-Piperazin-2-One
CAS No.	1217608-77-9
Molecular Formula	C11H14N2O3
Molecular Weight	222.24 g/mol
Synonyms	(R)-1-(4-Hydroxyphenyl)-6-(hydroxymethyl)piperazin-2-one; (R)-6-Hydroxymethyl-1-(4-hydroxy-phenyl)-2-piperazinone; (R)-enantiomer of 6-Hydroxymethyl-1-(4-Hydroxy-Phenyl)-Piperazin-2-One; (R)-HMPP; (R)-1-(4-Hydroxyphenyl)-6-(hydroxymethyl)-2-piperazinone; (R)-configuration Piperazinone derivative; (R)-6-(Hydroxymethyl)-1-(4-hydroxyphenyl)piperazin-2-one
EINECS	Contact for details

Quality Control

Our (R)-6-Hydroxymethyl-1-(4-Hydroxy-Phenyl)-Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.