Description

(R)-1-Boc-2-Isobutyl-Piperazine is a high-purity, non-natural amino acid derivative and a key chiral building block in organic synthesis. This compound matters for its role as a critical intermediate in the development of sophisticated pharmaceutical agents, particularly in the creation of active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics Research: Used in the design and construction of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in asymmetric catalytic reactions to introduce stereochemical complexity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling and hydrogenation reactions.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and cGMP manufacturing of advanced intermediates.

Basic Information

Item	Details
Product Name	(R)-1-Boc-2-Isobutyl-Piperazine
CAS No.	1217599-13-7
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-(2-methylpropyl)piperazine; (R)-2-Isobutyl-1-Boc-piperazine; tert-Butyl (R)-2-isobutylpiperazine-1-carboxylate; (R)-N-Boc-2-isobutylpiperazine; (R)-1-Boc-2-(2-methylpropyl)piperazine; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-(2-methylpropyl)piperazine; (R)-1-Boc-2-isobutylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-Isobutyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.