Description

Vildagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a key active pharmaceutical ingredient (API) in the treatment of type 2 diabetes. Its primary value lies in its ability to enhance glycemic control by increasing the levels of incretin hormones, which stimulate insulin release in a glucose-dependent manner. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing and producing antidiabetic medications, including combination therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral antidiabetic drugs for managing type 2 diabetes mellitus.
• Fixed-Dose Combination Drugs: Used in combination with other antidiabetic agents like metformin to create synergistic therapeutic effects.
• Research & Development: Critical for preclinical and clinical studies investigating new diabetes treatments and DPP-4 inhibitor mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Formulation Development: Utilized in the development of various dosage forms, including tablets and capsules.
• Metabolic Disorder Research: A tool compound for studying the role of DPP-4 in metabolism and related disorders beyond diabetes.

Basic Information

Product Name	Vildagliptin
CAS No.	1217546-82-1
Molecular Formula	C17H25N3O2
Molecular Weight	303.40 g/mol
Synonyms	LAF237; NVP-LAF-237; (2S)-1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-pyrrolidinecarbonitrile; 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine; Galvus (brand name)
EINECS	Contact for details

Quality Control

Our Vildagliptin is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is assured through comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for every batch, confirming compliance with in-house specifications aligned with major pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.