Description

2-Bromo-4-(Fluoromethyl)Pyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and a fluoromethyl group on the pyridine ring, makes it an invaluable intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form complex biaryl structures.
• Fluorine Chemistry: The fluoromethyl group is utilized to introduce fluorine into molecules, a common strategy in medicinal chemistry to modulate lipophilicity, bioavailability, and metabolic profile.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Product Name	2-Bromo-4-(Fluoromethyl)Pyridine
CAS No.	1217503-16-6
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	4-(Fluoromethyl)-2-bromopyridine; 2-Bromo-4-(fluoromethyl)pyridine; Pyridine, 2-bromo-4-(fluoromethyl)-; 2-Bromo-4-fluoromethylpyridine; 2-Br-4-FCH2-Py; 1217503-16-6 (CAS); 2-Bromo-4-fluoromethyl-pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Fluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.