Description

(R)-1-n-Boc-2-Isobutylpiperazine-Hcl is a high-purity, single-enantiomer chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry where stereochemical purity is paramount. It is primarily used by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral targets.
• Peptidomimetic Chemistry: Used in the construction of peptidomimetics and constrained peptide analogs due to its piperazine scaffold and protected amine functionality.
• Asymmetric Synthesis: Serves as a chiral auxiliary or a starting material for the preparation of other enantiomerically pure compounds in asymmetric synthesis.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for catalysis and organometallic complexes.
• Chemical Biology Research: Utilized as a probe or building block in chemical biology for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry & Scale-up: Suitable for process development and scale-up activities from milligram to kilogram scale under GMP or non-GMP conditions.

Basic Information

Product Name	(R)-1-n-Boc-2-Isobutylpiperazine Hydrochloride
CAS No.	1217482-29-5
Molecular Formula	C13H27N3O2 • HCl
Molecular Weight	293.84 g/mol (as free base: 257.37)
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-isobutylpiperazine hydrochloride; (R)-N-Boc-2-isobutylpiperazine HCl; (R)-1-Boc-2-(2-methylpropyl)piperazine hydrochloride; tert-Butyl (R)-2-isobutylpiperazine-1-carboxylate hydrochloride; (R)-2-Isobutyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; BOC-(R)-2-isobutylpiperazine HCl; (R)-1-Boc-2-isobutylpiperazine HCl
EINECS	Contact for details

Quality Control

Our (R)-1-n-Boc-2-Isobutylpiperazine-Hcl is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity suitable for advanced research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 quality management standards, and material can be supplied under GMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.