Description

(S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl is a high-purity chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring specific chiral centers.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used in the design and construction of peptide-like molecules for drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral complexity.
• API Development: Integral in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) requiring the (S)-piperazine-2-carboxylate motif.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological targets and pathways.
• Custom Synthesis: Serves as a foundational substrate for contract research organizations (CROs) and CDMOs performing bespoke synthetic routes.

Basic Information

Item	Details
Product Name	(S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl
CAS No.	1217471-97-0
Molecular Formula	C15H21N2O4 • HCl
Molecular Weight	344.80 g/mol
Synonyms	(S)-1-CBZ-4-PIPERAZINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE; (S)-Methyl 1-[(benzyloxy)carbonyl]piperazine-2-carboxylate hydrochloride; (S)-Methyl 4-(benzyloxycarbonyl)piperazine-2-carboxylate hydrochloride; (S)-Methyl 1-Cbz-piperazine-2-carboxylate HCl; (S)-1-N-CBZ-Piperazine-2-carboxylic acid methyl ester hydrochloride; (S)-1-Carbobenzyloxy-4-piperazinecarboxylic acid methyl ester HCl; (S)-1-Cbz-4-piperazinecarboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.