Description

(S)-4-n-Boc-2-Isobutyl-Piperazine-Hcl CAS NO 1217471-24-3 is a high-purity, single-enantiomer chiral piperazine derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in providing a stereochemically defined scaffold for constructing complex pharmaceutical molecules, particularly in the development of targeted therapeutics. This advanced intermediate is essential for research and production chemists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality chiral synthons for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology, antiviral, and central nervous system (CNS) drug candidates.
• Peptidomimetic Chemistry: Used to introduce the (S)-2-isobutylpiperazine moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: A versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Process Chemistry & Scale-Up: Suitable for use in developing robust and scalable synthetic routes from laboratory to pilot plant and commercial production.
• Protease Inhibitor Development: Found in the synthetic pathways of inhibitors targeting various proteases due to its structural similarity to natural amino acid derivatives.

Basic Information

Item	Details
Product Name	(S)-4-n-Boc-2-Isobutyl-Piperazine-Hcl
CAS No.	1217471-24-3
Molecular Formula	C13H27N2O2 • HCl
Molecular Weight	278.83 g/mol (Free base: 243.37 g/mol)
Synonyms	(S)-1-Boc-4-(2-methylpropyl)piperazine-2-carboxylic acid hydrochloride; (S)-tert-Butyl 4-(isobutyl)piperazine-1-carboxylate hydrochloride; (S)-N-Boc-2-isobutylpiperazine hydrochloride; (S)-1-(tert-Butoxycarbonyl)-2-isobutylpiperazine hydrochloride; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(2-methylpropyl)piperazine-2-carboxylic acid hydrochloride; (S)-4-(2-Methylpropyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid hydrochloride; BOC-(S)-2-Isobutylpiperazine HCl
EINECS	Contact for details

Quality Control

Our (S)-4-n-Boc-2-Isobutyl-Piperazine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided and available upon request. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.