Description

(R)-4-n-Boc-2-Isobutylpiperazine-Hcl CAS NO 1217469-14-1 is a high-purity, chiral piperazine derivative used as a critical building block in advanced pharmaceutical synthesis. This compound is essential for the development of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in therapeutic areas requiring stereochemical precision. It is primarily targeted at research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and antiviral targets.
• API Development: Serves as a crucial building block in the research and scale-up of new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to introduce the (R)-configured piperazine moiety.
• Peptidomimetics & Medicinal Chemistry: Integral for constructing peptidomimetic scaffolds and modifying pharmacokinetic properties in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	(R)-4-n-Boc-2-Isobutylpiperazine Hydrochloride
CAS No.	1217469-14-1
Molecular Formula	C13H27N3O2 • HCl
Molecular Weight	293.84 g/mol (as hydrochloride salt)
Synonyms	(R)-1-Boc-4-(2-methylpropyl)piperazine hydrochloride; (R)-tert-Butyl 4-(2-methylpropyl)piperazine-1-carboxylate hydrochloride; (R)-N-Boc-2-Isobutylpiperazine hydrochloride; (R)-4-(tert-Butoxycarbonyl)-2-isobutylpiperazine HCl; (R)-2-Isobutyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; (R)-1-(tert-Butoxycarbonyl)-2-isobutylpiperazine hydrochloride; (R)-Boc-2-Isobutylpiperazine HCl
EINECS	Contact for details

Quality Control

Our (R)-4-n-Boc-2-Isobutylpiperazine-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.