Description

1-Piperazinecarboxylic Acid, 3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, Hydrochloride (1:1), (3R)- is a high-purity, chiral piperazine derivative of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical building block and intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is essential for research institutions and manufacturers engaged in the development of complex small-molecule drugs, including protease inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting viral and neurological diseases.
• Protease Inhibitor Research: Used in the research and development of novel protease inhibitors due to its piperazine core structure.
• Peptidomimetics: Serves as a crucial component in the design and synthesis of peptidomimetic compounds for drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in asymmetric synthesis to introduce stereogenic centers with high enantiomeric purity.
• Chemical Biology: Utilized in the development of chemical probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) specializing in custom pharmaceutical intermediates.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, Hydrochloride (1:1), (3R)-
CAS No.	1217444-84-2
Molecular Formula	C11H23ClN2O3
Molecular Weight	266.77 g/mol
Synonyms	(3R)-3-(Hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate hydrochloride; (R)-N-Boc-3-(hydroxymethyl)piperazine hydrochloride; (R)-1-Boc-3-(hydroxymethyl)piperazine HCl; (R)-3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester hydrochloride; (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate HCl; (3R)-1-Boc-3-piperazinemethanol hydrochloride; (R)-1-N-Boc-3-piperazinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and residual solvent analysis by GC. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.