Description

(4S)-4-[(1S)-1-Methylpropyl]-3-Piperidin-4-Yl-1,3-Oxazolidin-2-One Hydrochloride is a high-purity, non-racemic chiral building block and advanced pharmaceutical intermediate. Its defined stereochemistry and complex heterocyclic structure make it a critical component for the synthesis of novel, biologically active compounds. This intermediate is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in the construction of complex molecules requiring specific stereocenters, leveraging its oxazolidinone and piperidine motifs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control of related compounds.

Basic Information

Product Name	(4S)-4-[(1S)-1-Methylpropyl]-3-Piperidin-4-Yl-1,3-Oxazolidin-2-One Hydrochloride
CAS No.	1217444-59-1
Molecular Formula	C12H22N2O2 • HCl
Molecular Weight	262.78 g/mol (Free base: 226.32 g/mol)
Synonyms	(4S)-4-[(1S)-sec-Butyl]-3-(4-piperidinyl)-2-oxazolidinone hydrochloride; 3-(Piperidin-4-yl)-4-[(1S)-sec-butyl]-1,3-oxazolidin-2-one hydrochloride (4S,1'S); 4-[(1S)-1-Methylpropyl]-3-(4-piperidinyl)-2-oxazolidinone hydrochloride (4S); (4S)-4-[(1S)-1-Methylpropyl]-3-(4-piperidinyl)-2-oxazolidinone monohydrochloride; UNII-1Q4K3S3W8H; 1Q4K3S3W8H; Oxazolidinone-piperidine hydrochloride intermediate.
EINECS	Contact for details

Quality Control

Our (4S)-4-[(1S)-1-Methylpropyl]-3-Piperidin-4-Yl-1,3-Oxazolidin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for advanced research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.