Description

(R)-4-n-Boc-2-Isopropylpiperazine-Hcl is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters because it provides a protected, enantiomerically pure scaffold essential for constructing complex molecules with defined stereochemistry. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications such as the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including potential CNS drugs and enzyme inhibitors.
• API Synthesis: Used in the construction of complex molecular architectures for Active Pharmaceutical Ingredients (APIs), leveraging its stereogenic center.
• Medicinal Chemistry: Serves as a versatile building block for creating focused libraries of compounds in drug discovery programs.
• Process Chemistry: Employed in route scouting and scale-up synthesis for the production of enantiomerically pure compounds.
• Asymmetric Synthesis: Acts as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetic compounds due to its piperazine core.

Basic Information

Product Name	(R)-4-n-Boc-2-Isopropylpiperazine-Hcl
CAS No.	1217444-26-2
Molecular Formula	C12H25ClN2O2
Molecular Weight	264.79 g/mol
Synonyms	(R)-1-tert-Butyl 4-(2-isopropylpiperazin-1-yl) 1,4-dicarboxylate hydrochloride; (R)-1-Boc-2-isopropylpiperazine hydrochloride; (R)-N-Boc-2-isopropylpiperazine HCl; (R)-2-Isopropyl-1-piperazinecarboxylic acid tert-butyl ester hydrochloride; tert-Butyl (R)-2-isopropylpiperazine-1-carboxylate hydrochloride; (R)-4-(tert-Butoxycarbonyl)-2-isopropylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-4-n-Boc-2-Isopropylpiperazine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.