Description

(S)-1-Benzyl 2-Methyl Piperazine-1,2-Dicarboxylate Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereochemical complexity.
• Peptidomimetic Research: Employed in the design and synthesis of peptide analogs and constrained scaffolds for medicinal chemistry.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Intermediate in the production of advanced, enantiomerically pure crop protection agents.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical spaces in organic chemistry.

Basic Information

Product Name	(S)-1-Benzyl 2-Methyl Piperazine-1,2-Dicarboxylate Hydrochloride
CAS No.	1217444-22-8
Molecular Formula	C15H20N2O4 • HCl
Molecular Weight	328.79 g/mol (Free base: 292.33 g/mol)
Synonyms	1-Benzyl (2S)-2-methylpiperazine-1,2-dicarboxylate hydrochloride; (S)-1-Benzyl 2-methylpiperazine-1,2-dicarboxylate HCl; (2S)-1-[(Benzyloxy)carbonyl]-2-methylpiperazine-2-carboxylic acid hydrochloride; Cbz-(S)-2-methylpiperazine-2-carboxylic acid hydrochloride; (S)-1-Cbz-2-methylpiperazine-2-carboxylic acid hydrochloride; (S)-N-Cbz-2-methylpiperazine-2-carboxylic acid hydrochloride; Chiral Cbz-protected methylpiperazine carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-Benzyl 2-Methyl Piperazine-1,2-Dicarboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.