Description

R-1-n-Boc-2-Ethyl-Piperazine-Hcl is a high-purity, protected piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for introducing the ethyl-piperazine moiety under controlled conditions, enabling the development of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry and functional group protection are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• API Synthesis: Serves as a protected precursor for constructing the piperazine core in active pharmaceutical ingredients (APIs), ensuring regioselectivity during multi-step syntheses.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the ethyl-piperazine structure contributes to biological activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under GMP or non-GMP conditions.
• Chemical Biology & Proteomics: Can be utilized as a scaffold or linker in the design of molecular probes and biochemical tools.

Basic Information

Product Name	R-1-n-Boc-2-Ethyl-Piperazine-Hcl
CAS No.	1217443-56-5
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	(R)-1-Boc-2-ethylpiperazine hydrochloride; (R)-1-(tert-Butoxycarbonyl)-2-ethylpiperazine hydrochloride; (R)-2-Ethyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; tert-Butyl (R)-2-ethylpiperazine-1-carboxylate hydrochloride; (R)-N-Boc-2-ethylpiperazine HCl; (R)-1-N-Boc-2-ethylpiperazine hydrochloride; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-ethylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our R-1-n-Boc-2-Ethyl-Piperazine-Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development from research to commercial scale with consistent quality and full regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.