Description

(R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl CAS NO 1217442-12-0 is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its primary value lies in its role as a key intermediate for constructing complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapeutics. This compound is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used in the design and construction of peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile chiral scaffold for introducing stereochemical complexity in medicinal chemistry programs.
• API Development: Employed in the research, development, and scale-up manufacturing of active pharmaceutical ingredients requiring a functionalized piperazine core.
• Chemical Biology Probes: Utilized in the creation of specialized molecular tools for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and contract research organizations (CROs/CMOs).

Basic Information

Product Name	(R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	1217442-12-0
Molecular Formula	C15H21N3O4 • HCl
Molecular Weight	359.81 g/mol (as hydrochloride salt)
Synonyms	(R)-Methyl 4-((benzyloxy)carbonyl)piperazine-2-carboxylate hydrochloride; (R)-1-CBZ-4-Piperazinecarboxylic Acid Methyl Ester Hydrochloride; (R)-Methyl 1-Cbz-piperazine-2-carboxylate hydrochloride; (R)-1-Benzyloxycarbonylpiperazine-2-carboxylic Acid Methyl Ester HCl; (R)-4-(Benzyloxycarbonyl)piperazine-2-carboxylic Acid Methyl Ester Hydrochloride; (R)-N-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester Hydrochloride; (2R)-4-[(Benzyloxy)carbonyl]piperazine-2-carboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture and prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.