Description

1-Boc-4-[2-(4-Carboxyphenoxy)Ethyl]Piperazine is a high-purity, multifunctional piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a protected, bifunctional intermediate with both a carboxylic acid and a Boc-protected secondary amine for selective functionalization. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), complex ligands, and specialty polymers, serving the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating complex molecular architectures for kinase inhibitors and receptor modulators.
• Peptidomimetic Synthesis: Serves as a scaffold or spacer in the design and synthesis of peptidomimetics and constrained peptides.
• Linker Chemistry: Used in bioconjugation and the development of antibody-drug conjugates (ADCs) due to its reactive carboxylic acid and protected amine groups.
• Polymer Science: Monomer for creating functionalized polymers and dendrimers with specific chemical handles for further modification.
• Chemical Biology Probes: Intermediate in the synthesis of fluorescent probes, affinity tags, and other tools for biochemical research.
• Agrochemical Research: Building block for developing new active ingredients with enhanced properties.
• Material Science: Used in the synthesis of advanced organic materials and metal-organic frameworks (MOFs).
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs for client-specific synthetic routes.

Basic Information

Product Name	1-Boc-4-[2-(4-Carboxyphenoxy)Ethyl]Piperazine
CAS No.	1216502-34-9
Molecular Formula	C19H28N2O5
Molecular Weight	364.44 g/mol
Synonyms	1-Boc-4-(2-(4-Carboxyphenoxy)ethyl)piperazine; tert-Butyl 4-[2-(4-carboxyphenoxy)ethyl]piperazine-1-carboxylate; 4-[2-(4-Carboxyphenoxy)ethyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-[2-(4-carboxyphenoxy)ethyl]piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-[2-(4-carboxyphenoxy)ethyl]-; BOC-Pip-C2-O-Ph-COOH
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[2-(4-Carboxyphenoxy)Ethyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.