Description

(S)-6-(3-Cyclopentyl-2-(4-(Trifluoromethyl)-1H-Imidazol- 1-Yl)Propanamido)Nicotinic Acid is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated intermediate, enabling the synthesis of targeted bioactive molecules with specific stereochemical configurations. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Bioconjugation & Probe Development: Potential use in the development of chemical probes, diagnostic agents, or antibody-drug conjugates (ADCs) due to its functionalized nicotinic acid moiety.
• Academic & Institutional Research: Employed in universities and research institutes for studying enzyme inhibition, receptor binding, and other biochemical mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	(S)-6-(3-Cyclopentyl-2-(4-(Trifluoromethyl)-1H-Imidazol- 1-Yl)Propanamido)Nicotinic Acid
CAS No.	1215197-37-7
Molecular Formula	C18H19F3N4O3
Molecular Weight	396.36 g/mol
Synonyms	(S)-6-[[3-Cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propanoyl]amino]nicotinic acid; (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-[[(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]-1-oxopropyl]amino]-; 1215197-37-7; (S)-enantiomer of the cyclopentyl-trifluoromethylimidazolyl propanamido nicotinic acid derivative.
EINECS	Contact for details

Quality Control

Our (S)-6-(3-Cyclopentyl-2-(4-(Trifluoromethyl)-1H-Imidazol- 1-Yl)Propanamido)Nicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.