Description

4-Oxo-27-Tbdms Withaferin A is a chemically modified derivative of the bioactive natural product Withaferin A, featuring a tert-butyldimethylsilyl (TBDMS) protecting group at the 27-position and a ketone at the 4-position. This derivative is primarily utilized as a critical synthetic intermediate in advanced pharmaceutical research and development, offering enhanced stability and reactivity for targeted chemical transformations. It is essential for medicinal chemists and research institutions focused on developing novel therapeutic agents, particularly in the fields of oncology, neuropharmacology, and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel Withanolide analogs for drug discovery programs.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) by modifying the Withaferin A core to enhance potency, selectivity, or pharmacokinetic properties.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, or NMR for the identification and quantification of related synthetic compounds.
• Biochemical Probe Development: Utilized in the creation of chemical probes to investigate specific biological pathways and protein targets associated with Withaferin A's mechanism of action.
• Process Chemistry: Acts as a protected intermediate in the scale-up synthesis of potential active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Supports fundamental research in organic synthesis and natural product chemistry at universities and R&D institutes.

Basic Information

Product Name	4-Oxo-27-Tbdms Withaferin A
CAS No.	1214886-31-3
Molecular Formula	C36H56O5Si
Molecular Weight	596.9 g/mol
Synonyms	27-[(tert-Butyldimethylsilyl)oxy]-4-oxowitha-2,24-dienolide; 4-Oxo-27-O-TBDMS Withaferin A; 27-O-TBDMS-4-oxowithaferin A; Withaferin A 27-TBDMS ether 4-one; 4-Oxowithaferin A 27-tert-butyldimethylsilyl ether; 4-Keto-27-TBDMS Withaferin A
EINECS	Contact for details

Quality Control

Our 4-Oxo-27-Tbdms Withaferin A is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.