Description

5-(tert-Butoxycarbonyl)Azepane-2-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the efficient and controlled construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel therapeutic agents, including protease inhibitors and GPCR modulators.
• Peptidomimetic Synthesis: Serves as a constrained, seven-membered ring (azepane) scaffold to mimic peptide secondary structures and enhance metabolic stability.
• Boc-Protection Chemistry: The tert-butoxycarbonyl (Boc) protecting group enables orthogonal deprotection strategies in multi-step synthetic sequences.
• Chemical Biology Probes: Used in the construction of specialized molecules for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing targeted compounds for clients.
• Academic Research: Employed in university and institutional labs for methodological development and the exploration of new chemical space in drug discovery.

Basic Information

Product Name	5-(tert-Butoxycarbonyl)Azepane-2-Carboxylic Acid
CAS No.	1214824-64-2
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	2-[(tert-Butoxy)carbonyl]azepane-5-carboxylic acid; 5-Boc-azepane-2-carboxylic acid; (2S)-2-[(tert-Butoxy)carbonyl]azepane-5-carboxylic acid (for enantiopure form); 1-Boc-5-carboxyazepane; tert-Butyl 5-carboxyazepane-2-carboxylate; Azepane-2-carboxylic acid, 5-[(1,1-dimethylethoxy)carbonyl]-; Boc-Aze(5)-OH (common peptide notation)
EINECS	Contact for details

Quality Control

Our 5-(tert-Butoxycarbonyl)Azepane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Keep container tightly sealed in a dry environment. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.