Description

Methyl 2-Bromo-3-Fluoroisonicotinate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a strategically halogenated and ester-functionalized pyridine core, enabling precise molecular construction in complex chemical architectures. Pharmaceutical, agrochemical, and material science researchers need it for developing novel active ingredients and functional molecules, leveraging its reactive sites for cross-coupling, substitution, and further derivatization.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in constructing advanced pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Precursor: Serves as a building block for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Fluorine Chemistry: The fluorine atom allows for studying structure-activity relationships (SAR) and improving metabolic stability in bioactive molecules.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	Methyl 2-Bromo-3-Fluoroisonicotinate
CAS No.	1214385-66-6
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	Methyl 2-bromo-3-fluoropyridine-4-carboxylate; 2-Bromo-3-fluoroisonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 2-bromo-3-fluoro-, methyl ester; 3-Fluoro-2-bromoisonicotinic acid methyl ester; Methyl 3-fluoro-2-bromoisonicotinate; 2-Bromo-3-fluoro-4-(methoxycarbonyl)pyridine
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-3-Fluoroisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.