Description

4-Cyano-3,5-Difluoropyridine is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with cyano and fluorine groups. This compound is essential for introducing the difluoropyridine pharmacophore into molecular scaffolds, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoropyridine moiety enhances biological activity.
• Material Science Research: Serves as a building block for creating functionalized ligands in catalysis and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Cyano-3,5-Difluoropyridine
CAS No.	1214377-09-9
Molecular Formula	C6H2F2N2
Molecular Weight	140.09 g/mol
Synonyms	3,5-Difluoropyridine-4-carbonitrile; 3,5-Difluoro-4-cyanopyridine; 4-Cyano-3,5-difluoropyridine; 4-Pyridinecarbonitrile, 3,5-difluoro-; 1214377-09-9
EINECS	Contact for details

Quality Control

Our 4-Cyano-3,5-Difluoropyridine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.