Description

4-Pyridinecarboxylic Acid, 3-Bromo-2-Fluoro- is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which introduces both bromine and fluorine substituents onto the pyridine-carboxylic acid scaffold, enabling precise modifications in target molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, where the halogenated pyridine core contributes to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized organic materials, such as metal-organic frameworks (MOFs) or organic semiconductors, where its carboxylic acid group allows for polymerization or coordination.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags, affinity probes, or other diagnostic tools used in biochemical research.
• Custom Synthesis and Scale-Up: An essential starting material for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	4-Pyridinecarboxylic Acid, 3-Bromo-2-Fluoro-
CAS No.	1214360-60-7
Molecular Formula	C6H3BrFNO2
Molecular Weight	219.99 g/mol
Synonyms	3-Bromo-2-fluoropyridine-4-carboxylic acid; 2-Fluoro-3-bromopyridine-4-carboxylic acid; 3-Bromo-2-fluoroisonicotinic acid; 4-Carboxy-3-bromo-2-fluoropyridine; 3-Bromo-2-fluoro-4-pyridinecarboxylic acid; 2-Fluoro-3-bromo-4-pyridinecarboxylic acid; 3-Bromo-2-fluoropyridine-4-carboxylate (anion form)
EINECS	Contact for details

Quality Control

Our production of 4-Pyridinecarboxylic Acid, 3-Bromo-2-Fluoro- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO standards for advanced intermediates, and specifications can be aligned with client-specific pharmacopeial or internal requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.