Description

5-Chloro-3-(trifluoromethyl)-2-pyridinecarbonitrile is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with chloro, trifluoromethyl, and nitrile groups. This unique combination of functional groups makes it a critical intermediate for the synthesis of advanced molecules, particularly in the agrochemical and pharmaceutical sectors. It is primarily sought after by research chemists and process development scientists for constructing complex active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Material Science Research: Serves as a starting material for creating functionalized ligands, organic semiconductors, and specialty polymers.
• Chemical Synthesis: Utilized in cross-coupling reactions, nucleophilic substitutions, and cyano-group transformations to access a diverse array of pyridine derivatives.

Basic Information

Product Name	5-Chloro-3-(trifluoromethyl)-2-pyridinecarbonitrile
CAS No.	1214349-71-9
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)picolinonitrile; 2-Cyano-5-chloro-3-(trifluoromethyl)pyridine; 5-Chloro-3-trifluoromethylpyridine-2-carbonitrile; 5-Chloro-3-(trifluoromethyl)-2-cyanopyridine; 2-Pyridinecarbonitrile, 5-chloro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-3-(trifluoromethyl)-2-pyridinecarbonitrile adheres to stringent in-process controls and final batch testing to ensure consistent purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality management system is designed to meet the rigorous demands of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.