Description

Ethyl 5-Chloro-2-Fluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing both halogen and fluorine substituents into complex molecular architectures, enabling precise modulation of biological activity and physicochemical properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Development: Used in creating novel herbicides and pesticides where the fluorine atom enhances metabolic stability and bioavailability.
• Chemical Research: Serves as a versatile precursor for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex heterocyclic systems.
• Material Science: Employed in the synthesis of fluorinated liquid crystals and organic electronic materials.
• Custom Synthesis: Provides a foundational structure for contract research organizations (CROs) and CDMOs to build custom molecules for client projects.

Basic Information

Product Name	Ethyl 5-Chloro-2-Fluoronicotinate
CAS No.	1214345-81-9
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	5-Chloro-2-fluoronicotinic acid ethyl ester; Ethyl 5-chloro-2-fluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-chloro-2-fluoro-, ethyl ester; 2-Fluoro-5-chloronicotinic acid ethyl ester; 1214345-81-9; 5-Chloro-2-fluoro-3-pyridinecarboxylic acid ethyl ester; Ethyl 5-chloro-2-fluoro-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Chloro-2-Fluoronicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.