Description

2-Pyridinecarboxylic Acid, 5-Bromo-6-Fluoro-, Methyl Ester is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its specific halogenated pyridine structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce bromine and fluorine substituents into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the bioactivity of halogenated pyridine motifs.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for advanced materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways due to its modifiable ester group.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 5-Bromo-6-Fluoro-, Methyl Ester
CAS No.	1214336-44-3
Molecular Formula	C8H5BrFNO2
Molecular Weight	246.03 g/mol
Synonyms	Methyl 5-Bromo-6-fluoropicolinate; 5-Bromo-6-fluoro-2-pyridinecarboxylic acid methyl ester; 5-Bromo-6-fluoropicolinic acid methyl ester; Methyl 5-bromo-6-fluoropyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 5-bromo-6-fluoro-, methyl ester; 5-Bromo-6-fluoro-2-(methoxycarbonyl)pyridine; Picolinic acid, 5-bromo-6-fluoro-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarboxylic Acid, 5-Bromo-6-Fluoro-, Methyl Ester is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.