Description

2-Bromo-3-Chloro-5-Fluoropyridine is a high-purity, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to construct advanced pyridine-based herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the reactive bromine substituent, enabling rapid diversification of molecular scaffolds.
• Ligand and Catalyst Development: Employed in the preparation of novel nitrogen-donor ligands for transition metal catalysis.
• Chemical Biology Probes: Used to create fluorinated and halogenated probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-Bromo-3-Chloro-5-Fluoropyridine
CAS No.	1214326-94-9
Molecular Formula	C5H2BrClFN
Molecular Weight	210.43 g/mol
Synonyms	2-Bromo-3-chloro-5-fluoropyridine; 3-Chloro-2-bromo-5-fluoropyridine; 5-Fluoro-3-chloro-2-bromopyridine; Pyridine, 2-bromo-3-chloro-5-fluoro-; 1214326-94-9; 2-Br-3-Cl-5-F-Py
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Chloro-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.