Description

3,5-Difluoro-Isonicotinic Acid Methyl Ester is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic incorporation of fluorine atoms and the versatile methyl ester group, enabling precise molecular modifications for enhanced bioactivity and material properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoro substitution pattern improves metabolic stability and binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystals for electronic applications.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Scale-up: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	3,5-Difluoro-Isonicotinic Acid Methyl Ester
CAS No.	1214324-60-3
Molecular Formula	C8H5F2NO2
Molecular Weight	185.13 g/mol
Synonyms	Methyl 3,5-Difluoropyridine-4-carboxylate; 3,5-Difluoropyridine-4-carboxylic Acid Methyl Ester; 4-Pyridinecarboxylic Acid, 3,5-Difluoro-, Methyl Ester; Methyl 3,5-Difluoroisonicotinate; 3,5-Difluoro-4-(methoxycarbonyl)pyridine; Isonicotinic Acid, 3,5-Difluoro-, Methyl Ester
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-Isonicotinic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.