Description

3-Chloro-6-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester is a high-value fluorinated pyridine derivative, a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, provides exceptional reactivity and physicochemical properties for creating complex molecules. This compound is essential for R&D and production chemists in the agrochemical and pharmaceutical industries, where it serves as a key intermediate for developing novel active ingredients.

Application

• Agrochemical Intermediate: A crucial precursor in the synthesis of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Material Science Research: Serves as a specialty monomer or additive in the development of advanced polymers, liquid crystals, and electronic materials.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to introduce the pyridine core into more complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and clinical trial materials.

Basic Information

Product Name	3-Chloro-6-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester
CAS No.	1214324-33-0
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 3-chloro-6-(trifluoromethyl)pyridine-2-carboxylate; 3-Chloro-6-(trifluoromethyl)picolinic acid methyl ester; 2-Pyridinecarboxylic acid, 3-chloro-6-(trifluoromethyl)-, methyl ester; Methyl 3-chloro-6-trifluoromethylpicolinate; 3-Chloro-6-trifluoromethyl-2-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-6-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.